Timolol and Epinephrine
- 1 March 1980
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 98 (3), 484-486
- https://doi.org/10.1001/archopht.1980.01020030480008
Abstract
• In a crossover design study, we assessed effects on intraocular pressure, pupillary diameter, pulse rate, and blood pressure over six hours of one drop of 0.5% timolol maleate and 2% epinephrine hydrochloride in one eye. Both eyes of each patient had been pretreated for one week with twice-daily applications of epinephrine or timolol, respectively. In random sequence, 20 patients (40 eyes) participated in both phases of the study. Pretreatment with timolol significantly reduced the ocular hypotensive effect of epinephrine (from 15.3% to 4.6%); epinephrine pretreatment did not affect the pressure reduction of timolol. Pretreatment with timolol enhanced the mydriatic effect of epinephrine (from 35.8% to 71.9% pupillary dilation); pretreatment with epinephrine resulted in an apparent mydriatic effect for timolol.This publication has 6 references indexed in Scilit:
- Cardiac Effects of Topical TimololNew England Journal of Medicine, 1979
- Timolol Plus Maximum-Tolerated Antiglaucoma TherapyArchives of Ophthalmology (1950), 1979
- Timolol: Its Effectiveness in Different Types of GlaucomaOphthalmology, 1979
- A Comparison of the Effects of Timolol and Epinephrine on Intraocular PressureAmerican Journal of Ophthalmology, 1978
- TimololArchives of Ophthalmology (1950), 1978
- TimololArchives of Ophthalmology (1950), 1977