STUDIES OF MICROBIAL POPULATIONS ARTIFICIALLY LOCALIZED IN VIVO. I. MULTIPLICATION OF BACTERIA AND DISTRIBUTION OF DRUGS IN AGAR LOCI 1

Abstract

The concns. necessary for inhibition of Salmonella typhosa in vitro and the concns. in the serum and extracellular fluid necessary to suppress the growth of typhoid bacilli in 3% agar discs in the peritoneal cavities of cats were equivalent. The doses of chlortetracycline required to yield inhibitory concns. in vivo were much larger than those of chloramphenicol and were greater than those ordinarily employed in clinical practice. This drug-host difference in the 2 drugs may be the critical factor in the disparity of their chemotherapeutic action and the weaker effect of chlortetracycline in typhoid fever in contrast to the more uniform response to treatment in other infections.