Estrogen Antagonisms: Inhibition of Estrone-Induced Uterine Growth by Testosterone Propionate, Progesterone and 17-ethyl-19-nortestosterone

Abstract

When given in combination with a 0.3 ug dose of estrone to intact, immature mice these 3 compounds caused a reduction in uterine growth expected from the estrone itself. This depression of response can be described satisfactorily with straight log dose-response lines. Progesterone had about 1.4 times and 17-ethyl-19-nortestosterone had about 70 times the antiestrogenic potency of testosterone propionate. This high activity of 17-ethyl-19-nortestosterone did not appear to correlate with androgenic, anabolic, pro-gestational or metrotropic properties.