Influence of enkephalin on K+-evoked efflux of putative neurotransmitters in rat brain
- 1 September 1977
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 299 (2), 163-165
- https://doi.org/10.1007/bf00498558
Abstract
In rat brain slices preincubated with various radiolabelled putative neurotransmitters, methionine-enkephalin diminished the potassium-evoked release of dopamine and acetylcholine. The effect was antagonised by naloxone. The potassium-induced efflux of three other neurotransmitters, histamine, 5-hydroxytryptamine and γ-aminobutyric acid, were unaffected by methionine-enkephalin. A probable physiological function for the endogenous ligands in specifically affecting the catecholaminergic and cholinergic transmission is suggested.Keywords
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