THE DEPENDENCE OF THE PATHOLOGICAL LESION UPON THE MULTIPLICATION OF PNEUMONIA VIRUS OF MICE (PVM)
Open Access
- 1 February 1951
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 93 (2), 139-150
- https://doi.org/10.1084/jem.93.2.139
Abstract
The rate of multiplication of PVM in the mouse lung is relatively constant, averaging 7.9-fold per day with but slight variations, irrespective of the amount of virus inoculated. Similarly, the rate of increase in the amount of pneumonia is relatively constant, averaging 4.7-fold per day, even though the quantity of virus inoculated is varied over a wide range. It follows that viral multiplication proceeds 1.7 times more rapidly than does extension of the pathological lesion, both reaching limiting maximal values in periods which are predictable from the amount of virus inoculated. From the concentration of virus determined at any time during the incremental period, the amount of pneumonia present earlier or later in the incremental period can be computed with considerable precision. The results support the postulate that the extent of the pathological lesion is dependent upon the degree of viral multiplication.Keywords
This publication has 10 references indexed in Scilit:
- THERAPY OF INFECTION WITH PNEUMONIA VIRUS OF MICE (PVM)The Journal of Experimental Medicine, 1951
- CHARACTERISTICS OF THE MULTIPLICATION CYCLE OF PNEUMONIA VIRUS OF MICE (PVM)The Journal of Experimental Medicine, 1951
- PROPERTIES OF PNEUMONIA VIRUS OF MICE (PVM) IN RELATION TO ITS STATEThe Journal of Experimental Medicine, 1947
- CENTRIFUGATION STUDIES ON PNEUMONIA VIRUS OF MICE (PVM)The Journal of Experimental Medicine, 1947
- STUDIES ON PNEUMONIA VIRUS OF MICE (PVM) : I. THE PRECISION OF MEASUREMENTS IN VIVO OF THE VIRUS AND ANTIBODIES AGAINST IT.1946
- STUDIES ON PNEUMONIA VIRUS OF MICE (PVM) : II. IMMUNOLOGICAL EVIDENCE OF LATENT INFECTION WITH THE VIRUS IN NUMEROUS MAMMALIAN SPECIES.1946
- Further Observations on Red Cell Agglutinating Agent Present in Lungs of Virus-Infected MiceExperimental Biology and Medicine, 1945
- A LATENT VIRUS IN NORMAL MICE CAPABLE OF PRODUCING PNEUMONIA IN ITS NATURAL HOSTThe Journal of Experimental Medicine, 1940
- NEUTRALIZATION OF EPIDEMIC INFLUENZA VIRUSThe Journal of Experimental Medicine, 1939