CENTRIFUGATION STUDIES ON PNEUMONIA VIRUS OF MICE (PVM)
Open Access
- 1 January 1947
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 85 (1), 23-38
- https://doi.org/10.1084/jem.85.1.23
Abstract
A technique has been devised for obtaining free or uncombined pneumonia virus of mice (PVM). Free PVM, liberated from infected mouse lungs by means of this technique, is infectious and causes hemagglutination directly. The results of quantitative studies carried out in the high speed angle centrifuge indicate that the free virus is relatively small, with dimensions of the order of 40 millimicrons. When it is in combination with lung tissue particles, PVM appears to be a relatively large virus with minimal dimensions of the order of 140 millimicrons. Non-infectious virus particles, released from combination with lung tissue particles by heating, are similar to the infectious free virus in size.Keywords
This publication has 9 references indexed in Scilit:
- PROPERTIES OF PNEUMONIA VIRUS OF MICE (PVM) IN RELATION TO ITS STATEThe Journal of Experimental Medicine, 1947
- STUDIES ON PNEUMONIA VIRUS OF MICE (PVM) : II. IMMUNOLOGICAL EVIDENCE OF LATENT INFECTION WITH THE VIRUS IN NUMEROUS MAMMALIAN SPECIES.1946
- Further Observations on Red Cell Agglutinating Agent Present in Lungs of Virus-Infected MiceExperimental Biology and Medicine, 1945
- CENTRIFUGATION AND ULTRAFILTRATION STUDIES ON ALLANTOIC FLUID PREPARATIONS OF INFLUENZA VIRUSThe Journal of Experimental Medicine, 1944
- SEDIMENTATION IN THE ANGLE CENTRIFUGEThe Journal of general physiology, 1943
- A LATENT VIRUS IN NORMAL MICE CAPABLE OF PRODUCING PNEUMONIA IN ITS NATURAL HOSTThe Journal of Experimental Medicine, 1940
- A METHOD FOR DETERMINING THE DIFFERENTIAL SEDIMENTATION OF PROTEINS IN THE HIGH SPEED CONCENTRATION CENTRIFUGEThe Journal of Experimental Medicine, 1938
- A HIGH SPEED VACUUM CENTRIFUGE SUITABLE FOR THE STUDY OF FILTERABLE VIRUSESThe Journal of Experimental Medicine, 1936