Human Proinsulin, IV. Synthesis of a Protected Peptide Fragment Corresponding to the Sequence 1-23 of the Prohormone
- 1 January 1980
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 361 (1), 839-848
- https://doi.org/10.1515/bchm2.1980.361.1.839
Abstract
The synthesis of the protected peptide fragment: Boc-Phe-Val-Asn-Gln-His-Leu-Cys-(Trt)-Gly-Ser(But)-His-Leu-Val-Glu(OBut)-Ala-Leu-Tyr(But)-Leu-Val-Cys(Trt)-Gly-Glu(OBut)-Arg(HCl)-Gly-OH, corresponding to the sequence 1-23 of human proinsulin (sequence 1-23 of human insulin B chain) is described. The fragment was synthesized from 2 intermediate fragments: 1-16 and 17-23 and was purified by gel filtration on Sephadex LH-20 in dimethylformamide.This publication has 9 references indexed in Scilit:
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