Comparison of Sonography and CT for Differentiating Benign from Malignant Cervical Lymph Nodes in Patients with Squamous Cell Carcinoma of the Head and Neck

Abstract

OBJECTIVE. We compared the ability of sonography and CT to differentiate benign from malignant cervical lymph nodes in patients with squamous cell carcinoma of the head and neck.MATERIALS AND METHODS. We analyzed 209 cervical nodes (102 metastatic and 107 nonmetastatic) from 62 patients with head and neck cancer. These nodes were topographically correlated by node between images and surgical specimens, and accordingly between sonography and CT.RESULTS. The area under the receiver operating characteristic curve (Az value) for the overall impressions of metastatic or nonmetastatic nodes was significantly greater for sonography (power Doppler sonography plus gray-scale sonography, 0.97 ± 0.005; gray-scale sonography, 0.95 ± 0.004) than for CT (0.87 ± 0.018). Receiver operating characteristic curve analysis also showed that the greater ability of sonography to depict the internal architecture of the nodes (Az value, 0.96 ± 0.006) compared with CT (Az value, 0.81 ± 0.027) significantly contributed to the bette...