CHANGES IN FOS/JUN BINDING-ACTIVITY ON A NEGATIVE REGULATORY ELEMENT OF C-MYC DURING DIFFERENTIATION OF MOUSE ERYTHROLEUKEMIC CELLS

Abstract

The binding activity of the AP-1 FOS/JUN complex to a negative regulatory element on the c-myc promoter was investigated and correlated with events characteristic of terminal differentiation of HMBA-induced mouse erythroleukemic cells. It is suggested that the altered AP-1 activity that was found upon induction of the erythroid differentiation may contribute to the late decline in c-myc mRNA.