Blockade of bradykinin-induced nociception in the rat as a test for analgesic drugs with particular reference to morphine antagonists

Abstract

A rat test, recently outlined by Deffenu & others for the evaluation of analgesic drugs and using intra-arterially administered bradykinin as the nociceptive stimulus, has been applied to varied categories of analgesic drugs including, for the first time, morphine antagonists. For purposes of comparison, data obtained with the same drugs using established techniques are also given. The use of the bradykinin-antagonism test as a laboratory model with which to investigate drugs of potential therapeutic value in man is discussed and compared particularly with the mouse phenylquinone-induced writhing test. Attention is drawn to the possibility of correlating the effect of drugs on bradykinin-induced pseudo-affective responses in animals with human pain.