Cytotaxin receptors of neutrophils: evidence that F-methionyl peptides and pepstatin share a common receptor

Abstract

Pepstatin, a chemotactic microbial pentapeptide, competes with f-Met-Leu-[3H]Phe for binding to human neutrophils. Porcine neutrophils, which neither specifically bind nor respond chemotactically to the synthetic f-methionyl peptides, do not respond chemotactically to pepstatin. Pepstatin may share a receptor on the neutrophil with f-methionyl peptides, despite their completely different amino acid compositions. The specificity of this cytotaxin receptor may be broader than expected and depend on ligand characteristics distinct from primary structure.