Increased Urinary Excretion of Cortisol and Catecholami-NES in Malnourished Cancer Patients
- 1 November 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Annals of Surgery
- Vol. 208 (5), 645-650
- https://doi.org/10.1097/00000658-198811000-00017
Abstract
Excretion of cortisol and catecholamines were measured from 24-hour urine samples collected over a period of 3 days from hospitalized cancer patients suffering from malnutrition and were compared with those of control patients equally malnourished and having a similar degree of inflammation. Compared with control patients, cancer patients had a higher excretion of cortisol, adrenaline, and noradrenaline, although noradrenaline excretion reached statistical significance only when normalized to creatinine excretion. Plasma glycerol concentrations after an overnight fast were significantly higher in cancer patients as compared with control patients, in keeping with an increased adrenal and adrenergic activity. This study demonstrates evidence of simultaneously elevated catecholamine and cortisol excretion in cancer patients, which could not be ascribed to alteration in body composition. The results may, in part, explain the mechanisms behind ongoing tissue breakdown in progressive cancer disease.This publication has 46 references indexed in Scilit:
- Urinary creatinine excretion and lean body massThe American Journal of Clinical Nutrition, 1976
- [Simultaneous column chromatography for the automatic determination of hormones (author's transl)].1975
- Cortisol Metabolism and the Pituitary-Adrenal Axis in Adults with Protein-Calorie MalnutritionJournal of Clinical Endocrinology & Metabolism, 1975
- Lactate metabolism in patients with cancerCancer, 1974
- Arm anthropometry in nutritional assessment: nomogram for rapid calculation of muscle circumference and cross-sectional muscle and fat areasThe American Journal of Clinical Nutrition, 1973
- Factors Influencing the Urinary Excretion of Free Catecholamines in ManClinical Science, 1973
- The relation of total body potassium to height, weight, and age in normal adultsJournal of Clinical Pathology, 1972
- Adrenal function in cancer: Relation to the evolutionEuropean Journal of Cancer (1965), 1971
- Free noradrenaline and adrenaline excretion in relation to clinical syndromes following myocardial infarctionThe American Journal of Cardiology, 1967
- The Estimation of Catechol Amines in UrineActa Physiologica Scandinavica, 1959