Influence of the MexAB-OprM Multidrug Efflux System on Quorum Sensing in Pseudomonas aeruginosa
Open Access
- 15 October 1998
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 180 (20), 5443-5447
- https://doi.org/10.1128/jb.180.20.5443-5447.1998
Abstract
Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellular virulence factors known to be regulated by quorum sensing. Such mutants also produce less acylated homoserine lactone autoinducer PAI-1, consistent with an observed reduction inlasI expression. These data suggest that PAI-1 is a substrate for MexAB-OprM, and its resulting exclusion from cells hyperexpressing MexAB-OprM limits PAI-1-dependent activation of lasI and the virulence genes.Keywords
This publication has 44 references indexed in Scilit:
- Characterization of MexE–MexF–OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosaMolecular Microbiology, 1997
- CENSUS AND CONSENSUS IN BACTERIAL ECOSYSTEMS: The LuxR-LuxI Family of Quorum-Sensing Transcriptional RegulatorsAnnual Review of Microbiology, 1996
- Overexpression of the mexC–mexD–oprJ efflux operon in nfxB‐type multidrug‐resistant strains of Pseudomonas aeruginosaMolecular Microbiology, 1996
- Enzymatic Synthesis of a Quorum-Sensing Autoinducer Through Use of Defined SubstratesScience, 1996
- Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1Molecular Microbiology, 1995
- Genes acrA and acrB encode a stress‐induced efflux system of Escherichia coliMolecular Microbiology, 1995
- Efflux pumps and drug resistance in Gram-negative bacteriaTrends in Microbiology, 1994
- Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicumGene, 1994
- Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdineMolecular Microbiology, 1993
- A Broad Host Range Mobilization System for In Vivo Genetic Engineering: Transposon Mutagenesis in Gram Negative BacteriaBio/Technology, 1983