Aluminium, β‐amyloid and non‐enzymatic glycosylation
- 8 May 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 364 (2), 182-184
- https://doi.org/10.1016/0014-5793(95)00388-p
Abstract
The non-enzymatic glycosylation of β-amyloid is implicated in the aetiology of Alzheimer's disease. However, controversy surrounds the nature of any involvement and a potential mechanism has not been fully elucidated. We present evidence of an aluminium-induced aggregation of the AβP(25–35) peptide and speculate that the mechanism of formation of our ordered β-amyloid aggregates might involve non-enzymatic glycosylation and/or site-specific crosslinking of β-amyloid fibrils by atomic aluminiumKeywords
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