The toxic effects of sporidesmin on mice

Abstract

The pathological changes produced in the bile ducts and livers of mice were in some respects similar to those produced in the other susceptible animals, and icterus was a usual symptom. In the experimental mice severe pleural effusions and pulmonary oedema were often the cause of death. Previously, sporidesmin-induced thoracic lesions have been seen only in rats and, to a lesser degree, in chickens.