AN ANALYSIS OF SV40-INDUCED TRANSFORMATION OF HAMSTER KIDNEY TISSUE IN VITRO, II. STUDIES OF THREE CLONES DERIVED FROM A CONTINUOUS LINE OF TRANSFORMED CELLS
- 1 November 1963
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 50 (5), 847-854
- https://doi.org/10.1073/pnas.50.5.847
Abstract
Virus was consistently recovered from all three clones only when they were planted directly on Cercopithecus Ridney cultures. This suggests that the SV40 genome is integrated in the genetic apparatus of a high proportion of transformed hamster kidney cells. Mixed tumors (carcinosarcomas) arose after transplantation of the epithelioid clones, indicating that a transformed cell may differentiate into cells with either an epithelial or fibroblastic morphology.Keywords
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