A novel muscarinic receptor ligand which penetrates the blood brain barrier and displays in vivo selectivity for the m2 subtype
- 31 December 1993
- journal article
- Published by Elsevier in Life Sciences
- Vol. 53 (23), 1743-1751
- https://doi.org/10.1016/0024-3205(93)90161-u
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- A novel m2-selective muscarinic antagonist: binding characteristics and autoradiographic distribution in rat brainBrain Research, 1992
- Binding of radioiodinated spect ligands to transfected cell membranes expressing single muscarinic receptor subtypesBiochemical and Biophysical Research Communications, 1991
- The Distribution of Cerebral Muscarinic Acetylcholine Receptors In Vivo in Patients With DementiaArchives of Neurology, 1991
- Quantitative autoradiography of M2 muscarinic receptors in the rat brain identified by using a selective radioligand [3H]AF-DX 116Brain Research, 1989
- Quantitative autoradiographic distribution of [3H]AF-DX 116 muscarinic-M2 receptor binding sites in rat brainSynapse, 1989
- Differential Alteration of Various Cholinergic Markers in Cortical and Subcortical Regions of Human Brain in Alzheimer's DiseaseJournal of Neurochemistry, 1988
- Distribution of muscarinic receptor subtypes in rat brain as determined in binding studies with AF-DX 116 and pirenzepineLife Sciences, 1987
- Muscarinic acetylcholine receptors in Alzheimer's disease. In vivo imaging with iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomographyJAMA, 1985
- Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic DenervationScience, 1985
- Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl .alpha.-hydroxy-.alpha.-(4-iodophenyl)-.alpha.-phenylacetate as potential radiopharmaceuticalsJournal of Medicinal Chemistry, 1984