Pseudopapillomata of the vesical and/or urethral mucosa were found in 195 patients among a total of 2046 patients at a Spinal Cord Injury Center. Of these, 169 cases were studied, and an incidence of 7.9% vesical and 1.6% urethral pseudopapillomatosis was found. Neither the age nor the level of the cord lesion seemed to play a significant role. Most pseudopapillomata were diagnosed in the first year after injury. Patients with catheters and pseudopapillomata outnumbered those without catheters 3 to 1. The role of infection and a high incidence of vesical and renal calculosis was demonstrated. Location of the bladder lesion seemed to favor the points of contact with the Foley bag. Therefore, it would be logical to replace Foley bag catheter drainage by whistle tip catheter drainage in spinal cord injury patients. Histological findings were described. The present policy of therapy at this Center was outlined. Recurrences were more frequent in the bladder than in the urethra. Electrofulguration appeared to be an effective modality of therapy. Biopsies are recommended because of potential, but rare, malignant degeneration.