Effect of Amygdaloid Lesions on Pituitary-Adrenal Axis in the Deermouse.

Abstract

Summary The effects of lesions in the medial amygdaloid complex in the deermouse on the pituitary-adrenal axis was investigated. Within 12 hours after lesions, plasma and pituitary ACTH increased significantly and remained significantly higher than control, unlesioned animals. The increases of ACTH also led to significant increases of plasma and adrenal corticosterone. It was concluded that the medial amygdaloid group possibly may exert an inhibitory effect on the pituitary-adrenal axis in the deermouse.