SYMPATHETIC VASODILATATION IN THE RABBIT EAR
Open Access
- 1 December 1962
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 19 (3), 513-526
- https://doi.org/10.1111/j.1476-5381.1962.tb01457.x
Abstract
Changes in the blood content of a 1 cm2 portion of the intact rabbit's ear were studied with transillumination and a photocell. Stimulation of the post-ganglionic sympathetic nerves produced a decrease in blood content, attributable to vasoconstriction, followed by an increased blood content, attributable to vasodilatation. The vasodilatation was enhanced by eserine and decreased by atropine. Guanethidine abolished the vasoconstriction but not the vasodilatation. After the ganglion had been decentralized by degeneration of the pre-ganglionic sympathetic nerves the vessels had an increased sensitivity to acetylcholine and the vasodilatation in response to sympathetic stimulation was enhanced. It is concluded that sympathetic stimulation results in the liberation of acetylcholine which causes vasodilatation.Keywords
This publication has 22 references indexed in Scilit:
- TISSUE AMINE LEVELS AND SYMPATHETIC BLOCKADE AFTER GUANETHIDINE AND BRETYLIUMBritish Journal of Pharmacology and Chemotherapy, 1961
- EFFECT OF GUANETHIDINE IN REVEALING CHOLINERGIC SYMPATHETIC FIBRESBritish Journal of Pharmacology and Chemotherapy, 1961
- TRANSMISSION FAILURE IN SYMPATHETIC NERVES PRODUCED BY HEMICHOLINIUMBritish Journal of Pharmacology and Chemotherapy, 1960
- THE ACTION OF SYMPATHETIC BLOCKING AGENTS ON ISOLATED AND INNERVATED ATRIA AND VESSELSBritish Journal of Pharmacology and Chemotherapy, 1960
- SYMPATHETIC POSTGANGLIONIC CHOLINERGIC FIBRESBritish Journal of Pharmacology and Chemotherapy, 1960
- THE ACTIONS OF BRETYLIUM: ADRENERGIC NEURONE BLOCKING AND OTHER EFFECTSBritish Journal of Pharmacology and Chemotherapy, 1959
- Noradrenaline in Artery Walls and its Dispersal by ReserpineBMJ, 1958
- THE BLOCKING ACTION OF CHOLINE 2:6-XYLYL ETHER BROMIDE ON ADRENERGIC NERVESBritish Journal of Pharmacology and Chemotherapy, 1957
- THE ACTION OF NICOTINE AND ACETYLCHOLINE ON THE VESSELS OF THE RABBIT'S EARBritish Journal of Pharmacology and Chemotherapy, 1953
- THE ACTION OF ANTAGONISTS OF ACETYLCHOLINE ON THE VESSELS OF THE RABBIT'S EARBritish Journal of Pharmacology and Chemotherapy, 1948