Effect of rifamycin derivatives and coumermycin A1 onin vitro RNA synthesis by African swine fever virus
- 1 March 1983
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 77 (1), 77-80
- https://doi.org/10.1007/bf01314866
Abstract
Several rifamycin derivatives inhibited the DNA-dependent RNA polymerase of African swine fever (ASF) virus particles. The inhibition was similar to that found with vaccinia virus RNA polymerase. Coumermycin A1, an inhibitor of type II DNA topoisomerases, inhibited strongly RNA synthesisin vitro by ASF virus particles. This suggests that transcription of ASF virus DNA requires a DNA topoisomerase.Keywords
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