Ultraviolet light action spectra for neoplastic transformation and lethality of Syrian hamster embryo cells correlate with spectrum for pyrimidine dimer formation in cellular DNA.
- 1 April 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (4), 2378-2382
- https://doi.org/10.1073/pnas.78.4.2378
Abstract
Action spectra were determined for neoplastic transformation, production of pyrimidine dimers and lethality in Syrian hamster embryo cells. Of wavelengths between 240-313 nm, the most effective were 265 and 270. The relative sensitivities per quantum for transformation, pyrimidine dimer production and lethality were essentially the same at each of the wavelengths tested. This action spectrum for transformation, which is relevant to carcinogenesis, is similar to spectra obtained previously by measuring other cellular responses in microbial or mammalian systems. Because the action spectra for cytotoxicity and transformation are the same as the spectrum for dimer production, DNA is suggested as the target for all these processes.This publication has 15 references indexed in Scilit:
- THE WAVELENGTH DEPENDENCE OF ULTRAVIOLET LIGHT—INDUCED CELL KILLING AND MUTAGENESIS IN L5178Y MOUSE LYMPHOMA CELLSPhotochemistry and Photobiology, 1981
- Ultraviolet wavelength regions implicated in toxic and mutagenic effects of broad spectrum radiation from fluorescent lamps on L5178Y mouse lymphoma cellsMutation Research, 1979
- Evidence that pyrimidine dimers in DNA can give rise to tumors.Proceedings of the National Academy of Sciences, 1977
- XERODERMA PIGMENTOSUM: BIOCHEMICAL AND GENETIC CHARACTERISTICSAnnual Review of Genetics, 1975
- The Wavelengths in Sunlight Effective in Producing Skin Cancer: A Theoretical AnalysisProceedings of the National Academy of Sciences, 1974
- Cyclobutane-Type Pyrimidine Dimers in PolynucleotidesScience, 1966
- Pyrimidine dimers in ultraviolet-irradiated DNA'sJournal of Molecular Biology, 1966
- Effects of ultraviolet radiation on mammalian cells I. Induction of chromosome aberrationsMutation Research, 1965
- The action spectra for ultraviolet-light inactivation of systems containing 5-bromouracil-substituted deoxyribonucleic acid☆II. Bacteriophage T4Biochimica et Biophysica Acta, 1963