The Effect of Sulfanilylguanidine on the Thyroid of the Rat

Abstract

Rats receiving sulfanilyl-guanidine in 1 or 2% levels had thyroids 3 to 8 times larger than normal which were hypertrophied and hyperemic. Histo-logically, the thyroids of the 2% sulfanilyl-guanidine rats showed marked hyperplasia. The epithelium was distinctly columnar and in most follicles so increased and invaginated as to nearly extinguish the lumen. But few of the lumina contained colloid, and where present it was vacuolated and shredded. The connective tissue was not appreciably increased, but the glands were very vascular.