Muscle-Derived Neurotrophin-4 as an Activity-Dependent Trophic Signal for Adult Motor Neurons
- 9 June 1995
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 268 (5216), 1495-1499
- https://doi.org/10.1126/science.7770776
Abstract
The production of neurotrophin-4 (NT-4) in rat skeletal muscle was found to depend on muscle activity. The amounts of NT-4 messenger RNA present decreased after blockade of neuromuscular transmission with alpha-bungarotoxin and increased during postnatal development and after electrical stimulation in a dose-dependent manner. NT-4 immunoreactivity was detected in slow, type I muscle fibers. Intramuscular administration of NT-4 induced sprouting of intact adult motor nerves. Thus, muscle-derived NT-4 acted as an activity-dependent neurotrophic signal for growth and remodeling of adult motor neuron innervation. NT-4 may thus be partly responsible for the effects of exercise and electrical stimulation on neuromuscular performance.Keywords
This publication has 33 references indexed in Scilit:
- Retrograde signaling in the formation and maintenance of the neuromuscular junctionJournal of Neurobiology, 1994
- Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.The Journal of cell biology, 1993
- The effects of exercise training of different intensities on neuromuscular junction morphologyJournal of Neurocytology, 1993
- The relationship of intramuscular nerve branching and synaptogenesis to motoneuron survivalJournal of Neurobiology, 1992
- Axonal sprouting and changes in fibre types after running-induced muscle damageJournal of Neurocytology, 1991
- Trophic factors and neuronal survivalNeuron, 1989
- Effect of low calcium and protease inhibitors on synapse elimination during postnatal development in the rat soleus muscleDevelopmental Brain Research, 1986
- Denervation increases a neurite-promoting activity in extracts of skeletal muscleNature, 1983
- The sequential development of nodal sprouts in mouse muscles in response to nerve degenerationJournal of Neurocytology, 1981
- Development of the Neuromuscular Junction: Inductive Interactions Between CellsAnnual Review of Neuroscience, 1981