Synthesis and biological activity of tetragastrin analogues modifying the tryptophan residue.
- 1 January 1977
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 25 (10), 2731-2734
- https://doi.org/10.1248/cpb.25.2731
Abstract
Three analogues of tetragastrin, in which the tryptophan residue was substituted by 3-(1-naphthyl)-L-alanine, 3-(2-naphthyl)-L-alanine or 1,2,3,4-tetrahydro-.beta.-carboline-3-carboxylic acid, were synthesized and evaluated for their gastric juice stimulating activity [in the rat]. Indolyl NH function in the tryptophan residue may play an important role, and the role of tryptophan residue in an interaction between tetragastrin and its receptor may be different from that in the case of luteinizing hormone-releasing hormone.This publication has 4 references indexed in Scilit:
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