Papillomavirus genomes in human cervical tumors: analysis of their transcriptional activity.
- 1 August 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (16), 5540-5544
- https://doi.org/10.1073/pnas.82.16.5540
Abstract
Four of 6 human cervical carcinoma biopsies were shown to contain the DNA of the human papillomavirus type 16 (HPV-16) covalently linked with the tumor cell DNA. HPV-16-specific mRNA species were observed in only 1 of the 4 tumors. No such sequences were found in the 3 other specimens in conditions that permitted the detection of less than one mRNA molecule per cell. Maintenance of the malignant nature of these cervical tumors does not depend on the continuous transcriptional activity of HPV-16.This publication has 38 references indexed in Scilit:
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