Comparative trial of amitriptyline‐N‐oxide and amitriptyline in the treatment of out‐patients with depressive syndromes

Abstract

Amitriptyline-N-oxide and amitriptyline were compared [double-blind] in out-patients with depressive syndromes, 21 and 22 patients, respectively. Both drugs had a good antidepressant effect. The globally rated effect and the effect upon the various depressive symptoms was equal. Definite reversal of depression occurred somewhat earlier with amitriptyline-N-oxide. Side-effects, both those of an anticholinergic and of a sedative nature were also less marked. No orthostatic reaction or any effect upon blood status or liver function, was observed. Amitriptyline-N-oxide apparently had a more rapid onset of effect and fewer side-effects.