Killer toxin from Hansenula mrakii selectively inhibits cell wall synthesis in a sensitive yeast
- 3 March 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 197 (1-2), 50-54
- https://doi.org/10.1016/0014-5793(86)80296-4
Abstract
Hansenula mrakii secretes extracellularly a killer toxin which kills sensitive Saccharomyces cerevisiae. In protoplasts of this yeast, the killer toxin selectively inhibited the synthesis of alkali-insoluble acid-insoluble polysaccharides consisting mainly of β-glucan, but did not inhibit either the synthesis of other cell wall polysaccharides, such as mannan, chitin and alkali-insoluble acid-soluble polysaccharides, or the synthesis of protein. Consistent with these results, the toxin was inhibitory to the β-(1,3)-glucan synthetase activity of a cell-free extract from sensitive S. cerevisiae.Keywords
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