Renin induced proteinuria and the effects of adrenalectomy - I. Haemodynamic changes in relation to function

Abstract

The degree of proteinuria induced by different pressor doses of pig renin, angiotensin II, adrenaline and noradrenaline in rats and the permissive role played by the adrenals in this respect, were investigated. No direct relationship could be established between elevation of blood pressure and proteinuria. A significant correlation was instead found between the increase in filtration fraction produced by these substances and their proteinuric effect. The absence of proteinuria in adrenalectomized rats was attributed to the severe impairment of renal blood supply caused by adrenalectomy. Corticosterone administration restored in four out of eight cases normal renal function and a normal proteinuric response to renin and angiotensin.