Strain Specificity and Production of Antibiotic Substances

Abstract
Five strains of A. oryzae had little or no antibacterial activity. Six strains of A. flavus did, the amt. depending on the strain, the medium (max. in corn steep) and aeration. This action is due to aspergillic acid affecting both gram + and - bacteria and fiavicin comparable if not identical with penicillin. The amt. of fiavicin produced by best strain was similar to best production of penicillin.