2,3-Dihydroxy-9-amino-9,10-dihydrophenanthrene, a rigid congener of dopamine and isoapomorphine
- 1 April 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (4), 395-398
- https://doi.org/10.1021/jm00202a017
Abstract
A rigid dopamine congener, 2,3-dihydroxy-9-amino-9,10-dihydrophenanthrene, was synthesized and tested for the ability to dilate the renal artery in dogs. The compound was inactive in this assay at molar doses 1000 times greater than required for dopamine. This result is similar to isoapomorphine. The title compound was also examined for its ability to stimulate rat striatal adenylate cyclase. In concentrations of 10-100 .mu.M no effect was observed. The phenanthrene also showed no ability to block dopamine-induced stimulation of adenylate cyclase.Keywords
This publication has 1 reference indexed in Scilit:
- Centrally acting emetics. 8. Conformational aspects of certain dihydrophenanthrene congeners of apomorphineJournal of Medicinal Chemistry, 1974