Systemic inflammatory response predicts postoperative outcome in patients with liver metastases from colorectal cancer

Abstract

Background Few studies have investigated the Glasgow Prognostic Score (GPS) in patients with liver metastases from colorectal cancer (LM‐CRC). Methods The GPS was calculated as follows: patients with both an elevated level of CRP (>10 mg/L) and hypoalbuminemia (Alb P < 0.0001). Univariate analysis revealed that sex, number of hepatectomy, number of tumors, synchronous lung metastasis and CRP were associated with postoperative death. Multivariate analysis revealed that number of hepatectomy (odds ratio, 3.193; 95% CI, 1.093–9.330; P = 0.0338), number of tumors (odds ratio, 2.946; 95% CI, 1.094–7.931; P = 0.0325), synchronous lung metastasis (odds ratio, 3.424; 95% CI, 1.055–11.11; P = 0.0404) and CRP (odds ratio, 4.509; 95% CI, 1.313–15.49; P = 0.0167) were associated with postoperative death. Conclusions GPS is able to classify patients with LM‐CRC into three independent groups. Among the selected factors, CRP is considered an important and high sensitive predictor of postoperative death in such patients. J. Surg. Oncol. 2009;100:38–42.