METABOLISM OF SUDOXICAM BY RAT, DOG, AND MONKEY

Abstract

Sudoxicam [a nonsteroidal anti-inflammatory agent], N-(2-thiazolyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide, was prepared in radiolabeled form and administered to rats, dogs, and monkeys [rhesus]. Urine contained approximately 60, 25 and 49% of the label given to rats, dogs and monkeys, respectively; the remainder was cleared via feces. In addition to some unchanged drug, urine from all species examined contained 2 major metabolites. These were identified from their mass spectra as the thiohydantoic acid and thiourea resulting from scission of the thiazole ring of sudoxicam.