Regulation by ovarian factors of the LHRH-induced LH response in pituitary glands in situ or grafted under the kidney capsule in intact and ovariectomized rats
- 1 October 1989
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 123 (1), 41-45
- https://doi.org/10.1677/joe.0.1230041
Abstract
When pituitary glands from intact female rats are incubated with LHRH, the resulting LH release shows a biphasic pattern: an initial low rate of LH release (lag phase) is followed by a high rate. When pituitary glands from long-term ovariectomized rats are incubated, the rate of LH release is high throughout stimulation with LHRH. The disappearance of the lag phase might be due to increased LHRH release after ovariectomy and/or the disappearance of ovarian factors. To distinguish between these possibilities, pituitary glands which had been exposed to endogenous LHRH (pituitary glands in situ) or which had been unexposed to endogenous LHRH (pituitary glands transplanted under the kidney capsule) were incubated in the presence or absence of LHRH. Biphasic LH secretion patterns were observed during incubation with LHRH with the animal's own pituitary gland and with the transplanted pituitary gland from intact, but not from ovariectomized rats. Thus the disappearance of the lag phase after ovariectomy results from the absence of ovarian secretory products, rather than from increased release of LHRH. Journal of Endocrinology (1989) 123, 41–45Keywords
This publication has 3 references indexed in Scilit:
- The self-priming action of LHRH increases the low pituitary LH and FSH response caused by ovarian factors: observations in vitroJournal of Endocrinology, 1989
- STUDIES ON A PROTEIN SYNTHESIS DEPENDENT STEP IN LH RELEASE BY LH-RHActa Endocrinologica, 1979
- LH-RH-dependent synthesis of protein necessary for LH release from rat pituitary glands in vitroMolecular and Cellular Endocrinology, 1976