Nucleotide Formation as a Determinant of 5-Fluorouracil Response in Mouse Leukemias
- 18 November 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 154 (3751), 911-913
- https://doi.org/10.1126/science.154.3751.911-a
Abstract
Survival of mice bearing different transplantable leukemias and treated with 5-fluorouracil was compared with accumulation of drug nucleotides in vitro. There was significant correlation,suggesting that cellular capacity for conversion of the drug to nucleotides is a major determinant of inherent drug sensitivity of these leukemias.This publication has 6 references indexed in Scilit:
- Uptake as a Determinant of Methotrexate Response in Mouse LeukemiasScience, 1965
- EXPERIMENTAL AND CLINICAL USE OF FLUORINATED PYRIMIDINES IN CANCER CHEMOTHERAPY1963
- STUDIES ON FLUORINATED PYRIMIDINES .8. FURTHER BIOCHEMICAL AND METABOLIC INVESTIGATIONS1959
- Fluorinated Pyrimidines VI. Effects of 5-Fluorouridine and 5-Fluoro-2'-Deoxyuridine on Transplanted Tumors.Experimental Biology and Medicine, 1958
- Enzymes of uracil metabolism in the Ehrlich ascites tumour and mammalian liverBiochimica et Biophysica Acta, 1958
- Some reactions of adenosine and inosine phosphates in animal tissuesBiochimica et Biophysica Acta, 1953