ACTION OF METHYLENE BLUE ON BODY TEMPERATURE AND METABOLISM
Open Access
- 1 December 1931
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 54 (6), 827-845
- https://doi.org/10.1084/jem.54.6.827
Abstract
1. Methylene blue injected intravenously in white rats is hyperthermizing or hypothermizing according to the environmental temperature. 2. It causes an increase in metabolism at 28 degrees C. or above. At lower temperature it does not affect, or rather depresses, metabolism. 3. It does not seem likely that its hypermetabolic action is due to catalysis of cell oxidations. 4. In animals exposed to an atmosphere with a high partial pressure of oxygen, methylene blue causes pulmonary edema, much more rapidly than does oxygen alone.Keywords
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