Quantitative analysis of the pattern of activity in audio-epileptic seizures in rats.

Abstract

1309 white rats were tested for the occurrence of audio-epileptic seizures when stimulated by a Galton whistle in a cage in which the activity was recorded by means of spring devices. The temporal course of the following components was described: 1) initial running attack, 2) initial tonic state, 3) second running attack, 4) second tonic state, 5) clonic phase, 6) period of coma, 7) period of convulsive jumping. Except for the duration of the convulsive jumping the time characteristics were multi-modal with tendency for high points at 6 and 12 secs, and at multiples of these values. Arguments are advanced for considering the behavior as a form of epileptic attack rather than a form of neurotic behavior.