A Comparison of Drug-Metabolizing Capability in Isolated Viable Rat Hepatocytes and Renal Tubule Fragments
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 8 (2), 113-120
- https://doi.org/10.3109/00498257809060390
Abstract
1. The metabolism of a number of xenobiotics has been investigated in isolated viable rat hepatocytes and kidney tubule fragments in suspension. 2. The level of Phase I metabolism was very low in the kidney cells although such cells possess appreciable Phase II metabolic capacity. 3. These findings are discussed in relation to the physiological role of cytochrome P-450 and the conjugating enzymes, and the value of intact cell systems in assessing inter-organ differences in xenobiotic metabolism.This publication has 21 references indexed in Scilit:
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