Comparison of two continuous‐flow cell separators

Abstract

Two blood processors (IBM 2997 and Fenwal CS‐3000) were evaluated under similar conditions. Fifty‐four leukapheresis procedures with the 2997 resulted in a mean granulocyte yield of 19.4 × 10⁹ (42.5% efficiency), with a mean of 2.1 × 10¹¹ platelets (10.9% efficiency) per product. The CS 3000, at a whole blood flow rate of 50 ml/min, yielded a mean of 13.3 × 10⁹ granulocytes (39.2% efficiency) and 4.0 × 10¹¹ platelets (28.5% efficiency) during 63 leukapheresis procedures. At a flow rate of 60 ml/min, the mean yields of 20 leukapheresis procedures with the CS 3000 were 14.2 × 10⁹ granulocytes (30.5% efficiency) and 4.3 × 10¹¹ platelets (27.8% efficiency). Thirty‐four plateletpheresis procedures with the 2997 yielded a mean of 3.62 × 10¹¹ platelets (53.12% efficiency), and 2.70 × 10⁹ white cells. The mean CS‐3000 yield for 88 plateletpheresis procedures was 3.15 × 10¹¹ platelets (49.13% efficiency) with a mean white cell content of 0.67 × 10⁹. Granulocyte yields with the 2997 were greater than those obtained with the CS‐3000.