Complement c4b–null alleles in felty's syndrome
- 1 August 1988
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 31 (8), 984-989
- https://doi.org/10.1002/art.1780310807
Abstract
C4A and C4B allotypes were compared in 20 patients with Felty's syndrome (FS), 52 patients with rheumatoid arthritis (RA), and 55 control subjects. Nineteen of the FS patients had HLA–DR4. A C4B‐null allele was more frequent in the patients with FS (60%) than in either the RA patients (15%) or the control subjects (26%). Only the differences between patients with FS and those with RA remained statistically significant when DR4 positive subjects were compared. The C4B null allele may identify individuals within the rheumatoid population who are at risk of developing particular systemic complications.Keywords
This publication has 15 references indexed in Scilit:
- HLA DQα and DQβ restriction fragment length polymorphisms associated with Felty's syndrome and DR4-positive rheumatoid arthritisHuman Immunology, 1987
- Phenotyping of human complement component C4, a class-III HLA antigenBiochemical Journal, 1986
- Relationship between C4 null genes, HLA-D region antigens, and genetic susceptibility to systemic lupus erythematosus in Caucasian and Black AmericansThe American Journal of Medicine, 1986
- Immunogenetic heterogeneity of rheumatoid arthritis.Annals Of The Rheumatic Diseases, 1986
- Felty syndrome: autoimmune neutropenia or immune-complex-mediated disease?Rheumatology International, 1985
- The location ofC2, C4, andBF relative toHLA-B andHLA-DImmunogenetics, 1981
- HLA‐DRw4 in Felty's syndromeArthritis & Rheumatism, 1980
- Inherited structural polymorphism of the fourth component of human complement.Proceedings of the National Academy of Sciences, 1980
- Familial Felty's syndrome.Annals Of The Rheumatic Diseases, 1976
- Obstructive pulmonary disease in rheumatoid arthritisArthritis & Rheumatism, 1976