Assembly of Alzheimer‐like filaments from full‐length tau protein
- 10 January 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 337 (2), 135-138
- https://doi.org/10.1016/0014-5793(94)80260-2
Abstract
The principal fibrous component of neurofibrillary pathology in Alzheimer's disease, the paired helical filament, is formed from hyperphosphorylated microtubule-associated protein tau. Here we show that recombinant tau protein either in a non-phosphorylated state or following phosphorylation with brain extract can be assembled in vitro into filaments resembling those seen in Alzheimer's disease.Keywords
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