Production of ulcers in isolated frog gastric mucosa

Abstract

In the absence of external supplies of CO2 (normally required to neutralize the alkali formed concomitantly with the acid), ulcerations and perforations occurred in tied bags of isolated frog gastric mucosa showing a high rate of acid secretion. Tied mucosae with low rates of secretion showed little or no ulceration. Tied mucosae which failed to secrete acid, and open sheets of mucosa suffered no damage. Anaerobically, when mucosae produce neither acid nor mucus, no damage was observed. In the presence of adequate supplies of CO2, tied mucosae in bicarbonate saline were undamaged. In the absence of external supplies of CO2 the avg. QHCl was never greater than the average (Q02). In the presence of 5% CO2 some mucosae had an average QHCl greater than the highest (Q02) found and a maximum QHCl about twice the value of this (Q02)- Ulcers occur if the alkali formed by oxyntic cells remains unneutral-ized.