EFFECT OF CONTINUED ORAL ADMINISTRATION OF DIETHYLSTILBESTROL ON BLOOD PRESSURE, HEART RATE AND RESPIRATION OF ALBINO RATS

Abstract

Forty-five adult oophorectomized and 35 normal [male] rats received by stomach tube 1 mg. of diethylstilbestrol in alkaline aqueous medium daily for periods up to 100 days. The results indicate no deviation of any kind from the normal range of values for the blood pressure. Neither was any trend toward higher values indicated for any period throughout the time of the expt. nor for a considerable time after treatment. No effect was detectable on the heart rate or respiratory rate.