Three Kinds of Tumour‐Unique Surface Molecules on a Human T‐Cell Chronic Lymphocytic Leukaemia (T‐CLL) Detected by Monoclonal Antibodies
- 1 September 1987
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 26 (3), 237-246
- https://doi.org/10.1111/j.1365-3083.1987.tb02257.x
Abstract
Mouse monoclonal antibodies recognizing cell surface molecules on tumour cells from a patient with a T-cell chronic lymphatic leukaemia (T-CLL) have been produced. Three different types of idiotype-like cell surface structures were identified. One molecular had a relative molecular weight (Mr) of 90,000 under non-reduced conditions and of 42,000 upon reduction, which corresponds well to the T-cell receptor for antigen (T1). The two other molecules, which also behaved like unique tumour markers, have not previously been described, to our knowledge. One molecule was a monomer with an Mr of 74,000-80,000 when non-reduced and 80,000 upon reduction. The other idiotypic molecule was a dimer with a non-reduced Mr of 74,000-80,000, and 38,000 after reduction.This publication has 27 references indexed in Scilit:
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