Netilmicin: in-vitro activity compared with that of other aminoglycosides against Serratia marcescens
- 1 February 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 11 (2), 187-189
- https://doi.org/10.1093/jac/11.2.187
Abstract
The activity of netilmicin, a semisynthetic aminoglycoside, was compared with that of gentamicin, tobramycin, and amikacin against 100 clinical isolates of Serratia marcescens Minimum inhibitory concentrations (MIC) were determined by an agar dilution procedure. Denningamikacin resistance as an MIC of > 16 mg/1, and netilmicin, gentamicin and tobramycin resistance as an MIC >4 mg/1, 1% were resistant to amikacin, 3% to netilmicin, 8% to tobramycin, and 43% to gentamicin. The majority of isolates that were resistant to both gentamicin and tobramycin were sensitive to netilmicin. These results indicate that the activity of netilmicin against Ser. marcescens is closely comparable to that of amikacin.Keywords
This publication has 1 reference indexed in Scilit:
- Hospital Isolates of Serratia marcescens Transferring Ampicillin, Carbenicillin, and Gentamicin Resistance to Other Gram-Negative Bacteria Including Pseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 1979