Effects of low-molecular-weight heparin on platelets as compared with commercial heparin
- 1 August 1984
- journal article
- research article
- Published by Springer Nature in Zeitschrift für Die Gesamte Experimentelle Medizin
- Vol. 184 (4), 227-229
- https://doi.org/10.1007/bf01852381
Abstract
Five subjects were injected with 5,000 IU of commercial heparin and low-molecular-weight heparin at an interval of 20 days after each injection. Both heparins produced the same platelet factor 4 release immediately after administration (commercial heparin 114.6 ± 21.6ng/ml, low-molecular-weight heparin 113.1 ± 22.1 ng/ml). However, commercial heparin induced a more evident potentiating effect on ADP-induced platelet aggregation and was still present 60min after injection. Low-molecular-weight heparin had a higher anti-Xa-specific activity than that determined by activated partial thromboplastin time. The opposite was true for the commercial preparation.This publication has 10 references indexed in Scilit:
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