Toward Enhanced Pharmacovigilance Using Patient-Generated Data on the Internet
Open Access
- 8 April 2014
- journal article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 96 (2), 239-246
- https://doi.org/10.1038/clpt.2014.77
Abstract
The promise of augmenting pharmacovigilance with patient-generated data drawn from the Internet was called out by a scientific committee charged with conducting a review of the current and planned pharmacovigilance practices of the US Food and Drug Administration (FDA). To this end, we present a study on harnessing behavioral data drawn from Internet search logs to detect adverse drug reactions (ADRs). By analyzing search queries collected from 80 million consenting users and by using a widely recognized benchmark of ADRs, we found that the performance of ADR detection via search logs is comparable and complementary to detection based on the FDA’s adverse event reporting system (AERS). We show that by jointly leveraging data from the AERS and search logs, the accuracy of ADR detection can be improved by 19% relative to the use of each data source independently. The results suggest that leveraging nontraditional sources such as online search logs could supplement existing pharmacovigilance approaches.Keywords
This publication has 34 references indexed in Scilit:
- Novel Data-Mining Methodologies for Adverse Drug Event Discovery and AnalysisClinical Pharmacology & Therapeutics, 2012
- Facilitating adverse drug event detection in pharmacovigilance databases using molecular structure similarity: application to rhabdomyolysisJournal of the American Medical Informatics Association, 2011
- Using information mining of the medical literature to improve drug safetyJournal of the American Medical Informatics Association, 2011
- BioPortal: enhanced functionality via new Web services from the National Center for Biomedical Ontology to access and use ontologies in software applicationsNucleic Acids Research, 2011
- Predicting Adverse Drug Reactions Using Publicly Available PubChem BioAssay DataClinical Pharmacology & Therapeutics, 2011
- pROC: an open-source package for R and S+ to analyze and compare ROC curvesBMC Bioinformatics, 2011
- Validation of Statistical Signal Detection Procedures in EudraVigilance Post-Authorization DataDrug Safety, 2010
- Detecting influenza epidemics using search engine query dataNature, 2009
- Confidence limits for the ratio of two rates based on likelihood scores: non‐iterative methodStatistics in Medicine, 2003
- Crossover and Self-Controlled Designs in Clinical ResearchNew England Journal of Medicine, 1984