Effect of Diamox (Acetazoleamide) on the Carbon Dioxide Tension of the Urine

Abstract

In the anesthetized dog the pCO₂ of the urine, arterial blood, and renal venous blood was measured before and after the intravenous administration of Diamox (acetazoleamide). The pCO₂ of the urine always rose to a much greater degree than did the pCO₂ of the arterial or renal venous blood This rise in urinary pCO₂ could be explained satisfactorily neither by a rise in intracellular pCO₂ nor by an increase in the rate of urine flow, but seemed best explained by the fact that Diamox itself acted as a urinary buffer.