Pumilacidin, a complex of new antiviral antibiotics. Production, isolation, chemical properties, structure and biological activity.
- 1 January 1990
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 43 (3), 267-280
- https://doi.org/10.7164/antibiotics.43.267
Abstract
New antibiotic pumilacidins A, B, C, D, E, F and G were isolated from the culture broth of a strain of Bacillus pumilus. They are cyclic acylheptapeptide composed of a .beta.-hydroxy fatty acid, two L-leucine, two D-leucine, L-glutamine acid, L-aspartic acid and L-isoleucine (or L-valine). Pumilacidin components were inhibitory to herpes simplex virus type 1 and H+, K+-ATPase and demonstrated antiulcer activity in rat.This publication has 2 references indexed in Scilit:
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- Characterization of gastric mucosal membranes. IX. Fractionation and purification of K+-ATPase-containing vesicles by zonal centrifugation and free-flow electrophoresis techniqueBiochimica et Biophysica Acta (BBA) - Biomembranes, 1977