The role of prostaglandins in hypertension. I. The release of prostaglandins by aorta strips of renal, DOCA–salt, and spontaneously hypertensive rats

Abstract

The release of prostaglandin-like (PG-like) material by aorta strips of normotensive and hypertensive rats has been studied in vitro. When incubated in an oxygenated Krebs solution kept at 37 °C, aorta strips removed from 8- and 12-week-old spontaneously hypertensive (SH) rats generate 1.2–2.5 times more PG-like material than aorta strips from age-matched normotensive Wistar (NW) rats. The overproduction of PG-like material by aorta strips of SH rats did not precede the development of hypertension in SH rats. Aorta strips derived from renal and DOCA–salt hypertensive rats produced 1.5–3 times more PG-like material than aorta strips from NW rats. The production of PG-like material by aorta strips of renal and DOCA–salt hypertensive rats was largely reduced when hypertension was interrupted in these animals, thus suggesting that the alteration taking place in the arteries of hypertensive rats (namely increased production of PGs) during the development of hypertension was reversible. The production of PG-like material by aorta strips of hypertensive rats was inhibited by indomethacin.Analysis of the PG-like material by bioassays and thin-layer chromatography suggests the presence of PGE₂ and PGE₁. The possible involvement of these PGs in the pathogenesis of hypertension in rats is discussed.